Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male Mice [Prorenin Receptor]

We report a unique model of adipocyte-PRR–deficient mice (PRRAdi/Y) with almost no detectable white adipose tissues. As a consequence, the livers of PRRAdi/Y mice were enlarged and demonstrated a marked accumulation of lipids. Adipocyte-specific deficiency of PRR increased systolic blood pressure and the concentration of soluble PRR in plasma. To determine whether adipocyte-PRR was involved in the development of obesity-induced hypertension, mice were fed a low-fat or a high-fat diet for 16 weeks. Adipocyte-PRR–deficient mice were resistant to diet-induced obesity. Both high-fat– and low-fat–fed PRRAdi/Y mice had elevated insulin levels. Interestingly, adipocyte-PRR deficiency improved glucose tolerance in high-fat–fed PRRAdi/Y mice. In response to feeding either low-fat or high-fat diets, systolic blood pressure was greater in PRRAdi/Y mice than in control mice. High-fat feeding elevated soluble PRR concentration in control and PRRAdi/Y mice. In vitro knockdown of PRR by siRNA significantly decreased mRNA abundance of PPAR (peroxisome proliferator-activated receptor gamma), suggesting an important role for PRR in adipogenesis. Our data indicate that adipocyte-PRR is involved in lipid homeostasis and glucose and insulin homeostasis, and that soluble PRR may be a predictor of metabolic disturbances and play a role in systolic blood pressure regulation.
Source: Hypertension - Category: Cardiology Authors: Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, High Blood Pressure, Hypertension Prorenin Receptor Source Type: research