How Getting a Puppy Helped My Terminally Ill Teen
The puppy was 10 weeks old and a little over a pound the day we brought him home. He was a fancy mutt, a combination miniature poodle and Yorkshire terrier (yorkie-poo) that will likely grow no larger than five or six pounds. My 14-year-old daughter was in Manhattan getting radiation for tumors in her lungs the day I picked him up - he was a surprise that would be waiting for her that night. I'd originally told her we would get a dog when radiation treatments were over -- something for her to look forward to after three weeks of daily trips to the hospital (a six-hour round trip from our home in the Hudson Valley). I kept my younger daughter home from school the day we got him, mostly because I was terrified of being alone with a dog, even one so small. I've been a cat person all my life. "I don't know about this," I'd said as we drove away from the kennel. "This is the best day of my life," my daughter had responded. The puppy was curled up in her lap, looking a bit uncertain himself. We named him Roo (after the Winnie the Poo character) because he hopped around so much. He was my responsibility for the first month. My husband needed to focus on getting enough rest for the daily drives, and my older daughter, exhausted from the commute and double dose of radiation, barely had enough energy to greet him each evening before going upstairs to rest. "He smells," she said the first day. So I gave him a bath. Roo slept in a crate each night wi...
In this study, we constructed a novel herbal formula, SGE, which contains Ginseng Radix alba, Atractylodis Rhizoma alba, and Hoelen, examined its anti-cancer and anti-cachexia efficacies. In in vitro experiments, SGE induced death of CT-26 murine colon carcinoma cells via endoplasmic reticulum stress, and suppressed the production of inflammatory cytokines in Raw 264.7 murine macrophage-like cells. In addition, SGE treatment attenuated CT-26-induced C2C12 skeletal muscle cell atrophy as well as CT-26-induced reduction in lipid accumulation in 3T3-L1 adipocyte. In CT-26 tumor-bearing mice, daily oral administration of 10 an...
Conclusions: In our study, the results we presented showed apatinib might have a rapid, safe and high efficacy on relapsed or refractory non-Hodgkin lymphoma patients. Based on the data more clinic trials are expected to be taken to identification the efficacy of apatinib on lymphoma further. PMID: 29662638 [PubMed]
This study showed that ESE-16 exposure leads to the aggregation of acidic vesicles, identified as lysosomes, not accompanied by an induction of autophagy. Therefore, ESE-16 disrupts normal endocytic vesicle maturation likely through the inhibition of the microtubule function.Pharmacology 2018;102:9 –16
Introduction: Dermatologists prescribe more oral antibiotics per capita than any other specialty; this use may be associated with a number of adverse outcomes including antibiotic resistance, inflammatory bowel disease, and colon cancer, among others. Understanding the epidemiology of prescribing practices in Dermatology will help identify opportunities to optimize the use of antibiotics. Methods: All prescriptions for oral antibiotics written by dermatologists were identified from 2008-2016 in the de-identified Clinformatics DataMart.
UV radiation (UVR) induces pyrimidine dimer formation and generates reactive oxygen species leading to skin cancer and photoaging. Sunscreen and protective clothing are primary modalities for photoprotection, but rising skin cancer rates support the rationale for adding systemic photoprotective agents. We showed topical sulforaphane extracts from broccoli reduced erythema resulting from UVB irradiation in humans, and the antioxidant curcumin has well established its anti-inflammatory effects. However, it is not known whether the photoprotective effects of phytochemicals can be achieved through oral delivery.
Many antioxidants inhibit immune suppression and/or skin cancer formation in experimental animals exposed to UVB (280-320 nm) radiation. In this regard, PT has been shown to protect hairless mice against UVB radiation-induced skin damage and carcinogenesis. Nicotinamide has been shown to enhance and repair UVB-induced DNA damage in a transformed human keratinocyte line and in human skin ex vivo as well as in primary melanocytes. It also downregulates expression of some inflammatory peptides including IL-6, IL-10, monocyte chemoattractant protein 1 and tumor necrosis factor alpha in transformed human keratinocytes exposed to UVB radiation.
Overexposure to the sun leads to higher risk of photoaging and skin cancer. Until now the role of infrared (IR) and visible light (VL) radiations has not been taken into account in the pathogenesis of these processes. In addition to topical barrier products, oral supplementation of various botanicals endowed with antioxidant activity is emerging as a novel method of photoprotection. Thus, it has been reported that a natural extract from Polypodium leucotomos (PL, Fernblock ®) has antioxidant and photoprotective properties and exhibits a strong anti-aging effect.
Worldwide oral squamous cell carcinoma (OSCC) is one of the most frequent malignancies, with a mortality rate of 1.9 deaths per 100,000 per year. Most cases of OSCC are preceded by clinical lesions referred to as oral potentially malignant disorders (OPMDs). The World Health Organization defines OPMDs as “clinical presentations that carry a risk of cancer development in the oral cavity, whether in a clinically definable precursor lesion or in clinically normal oral mucosa”. These disorders include leukoplakia, erythroplakia, erythroleukoplakia, oral submucous fibrosis, palatal lesion of reverse cigar smoking an...
This cohort study evaluates the initiation of a proactive speech and language pathology rehabilitation program and its association with rates of feeding tube placement and posttreatment oral intake in patients with head and neck squamous cell carcinoma.
ConclusionsThe classification on T3 in the 8th edition can be seen as reasonable with regard to prognosis. Nodal metastasis was significantly correlated with T classification and DOI; however, the probability of subsequent nodal metastasis in patients with T2N0 was almost same for the criteria in the 7th and 8th editions, therefore, the same careful management as before is required for patients with N0 disease.