How Getting a Puppy Helped My Terminally Ill Teen

The puppy was 10 weeks old and a little over a pound the day we brought him home. He was a fancy mutt, a combination miniature poodle and Yorkshire terrier (yorkie-poo) that will likely grow no larger than five or six pounds. My 14-year-old daughter was in Manhattan getting radiation for tumors in her lungs the day I picked him up - he was a surprise that would be waiting for her that night. I'd originally told her we would get a dog when radiation treatments were over -- something for her to look forward to after three weeks of daily trips to the hospital (a six-hour round trip from our home in the Hudson Valley). I kept my younger daughter home from school the day we got him, mostly because I was terrified of being alone with a dog, even one so small. I've been a cat person all my life. "I don't know about this," I'd said as we drove away from the kennel. "This is the best day of my life," my daughter had responded. The puppy was curled up in her lap, looking a bit uncertain himself. We named him Roo (after the Winnie the Poo character) because he hopped around so much. He was my responsibility for the first month. My husband needed to focus on getting enough rest for the daily drives, and my older daughter, exhausted from the commute and double dose of radiation, barely had enough energy to greet him each evening before going upstairs to rest. "He smells," she said the first day. So I gave him a bath. Roo slept in a crate each night wi...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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A phase Ib dose-escalation and expansion study of the oral MEK inhibitor pimasertib and PI3K/MTOR inhibitor voxtalisib in patients with advanced solid tumours, Published online: 14 November 2018; doi:10.1038/s41416-018-0322-4A phase Ib dose-escalation and expansion study of the oral MEK inhibitor pimasertib and PI3K/MTOR inhibitor voxtalisib in patients with advanced solid tumours
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This article summarizes the milestones in the development of duvelisib leading to these first approvals for CLL/SLL and FL.
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In conclusion, this RCT was underpowered to indicate the efficacy of nanocurcumin in this clinical setti ng but could provide a considerable new translational insight to bridge the gap between the laboratory and clinical practice.
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Conclusions: The 43% 1-year survival for patients receiving bexarotene with weekly paclitaxel and monthly carboplatin is encouraging. With the availability of new classes of agents for lung cancer, further evaluation of this regimen in unselected patients is not warranted. Our study confirms prior subgroup analyses showing a significant correlation between bexarotene-induced hypertriglyceridemia and survival. Further research is needed to identify molecular biomarkers to identify this subset of patients and to explore rexinoids in other combinations, especially with immunotherapy. PMID: 30416803 [PubMed]
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Ovarian endometriotic cysts have been identified as the possible origin of ovarian clear cell carcinoma (OCCC), so predicting or preventing future transformation is important. Early detection of clear cell carcinoma is important because it shows low sensitivity to chemotherapy and the prognosis is worse than for other histologic types. We recently treated 2 patients with OCCC. They were both young women with no family history of cancer who received long-term oral contraceptive therapy for endometriotic cysts, and the histologic diagnosis was typical clear cell carcinoma in both patients. However, in Case 1, the tumor was d...
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