Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes

Conclusion
In adult cardiac myocytes, tortuosity due to physical barriers, notably mitochondria, restricts cAMP diffusion to levels that are more compatible with microdomain signalling.

Source: Cardiovascular Research - May 18, 2016 Category: Cardiology Authors: Richards, M., Lomas, O., Jalink, K., Ford, K. L., Vaughan-Jones, R. D., Lefkimmiatis, K., Swietach, P. Tags: Cardiac biology and remodelling Source Type: research