Liposarcoma: molecular targets and therapeutic implications.

Liposarcoma: molecular targets and therapeutic implications.
Cell Mol Life Sci. 2016 May 12;
Authors: Bill KL, Casadei L, Prudner BC, Iwenofu H, Strohecker AM, Pollock RE
Abstract
Liposarcoma (LPS) is the most common soft tissue sarcoma and accounts for approximately 20 % of all adult sarcomas. Current treatment modalities (surgery, chemotherapy, and radiotherapy) all have limitations; therefore, molecularly driven studies are needed to improve the identification and increased understanding of genetic and epigenetic deregulations in LPS if we are to successfully target specific tumorigenic drivers. It can be anticipated that such biology-driven therapeutics will improve treatments by selectively deleting cancer cells while sparing normal tissues. This review will focus on several therapeutically actionable molecular markers identified in well-differentiated LPS and dedifferentiated LPS, highlighting their potential clinical applicability.
PMID: 27173057 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - May 11, 2016 Category: Cytology Authors: Bill KL, Casadei L, Prudner BC, Iwenofu H, Strohecker AM, Pollock RE Tags: Cell Mol Life Sci Source Type: research