Abstract B02: Sonic hedgehog signaling in neuronal migration and tumorigenesis

Conclusion: We propose that Shh signaling prevents GNPs from exiting the EGL by maintaining the expression of Siah2 in a Ras-Erk dependent pathway. Differentiated CGNs retract the primary cilia, hence becoming insensitive to Shh allowing them to downregulate Siah2 to initiate GZ exit. Aberrant Shh signaling disrupts this developmental program by maintaining GNPs in the germinal zone which we postulate to be the initial step in Shh-MB tumorigenesis.Citation Format: Taren Ong, David J. Solecki. Sonic hedgehog signaling in neuronal migration and tumorigenesis. [abstract]. In: Proceedings of the AACR Special Conference: Developmental Biology and Cancer; Nov 30-Dec 3, 2015; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(4_Suppl):Abstract nr B02.
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Tags: Signaling Pathways: Hedgehog: Poster Presentations - Proffered Abstracts Source Type: research