Implication of Vasopressin in the vascular response to myocardial infarction and cardiogenic shock in a rat model

Acute heart failure (AHF) due to acute myocardial infarction (AMI) is likely to involve cardiogenic shock (CS) when early revascularization is not efficient. CS is a state of end-organ hypoperfusion consecutive to cardiac failure with neuro-hormonal activation. The increase of vasopressin (AVP) release has been associated with adverse outcome in AHF (1). AVP may be responsible for microcirculation alterations with inadequate tissue oxygenation (2) leading to multiple organs failure and death. The aim of the experimental study was to investigate the implication of AVP, studied by in vitro vascular reactivity, in the alterations of circulation observed in AMI and CS.

Source: Journal of Cardiothoracic and Vascular Anesthesia - April 30, 2016 Category: Anesthesiology Authors: Philippe Gaudard, H. David, C. Farah, P. Bideaux, S. Richard, A. Virsolvy, P. Colson Source Type: research