Selective phosphorylation of PKA targets after {beta}-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model

Conclusion
These data provide evidence that in the KI HCM mouse model, β-AR stimulation leads to preferential PKA phosphorylation of PLN over cTnI, resulting in an impaired inotropic and lusitropic response.

Source: Cardiovascular Research - April 18, 2016 Category: Cardiology Authors: Najafi, A., Sequeira, V., Helmes, M., Bollen, I. A. E., Goebel, M., Regan, J. A., Carrier, L., Kuster, D. W. D., Van Der Velden, J. Tags: Cardiac biology and remodelling Source Type: research