Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF Arrhythmia and Electrophysiology

Background Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS2 score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan–Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33–1.70, P
Source: JAHA:Journal of the American Heart Association - Category: Cardiology Authors: Tags: Atrial Fibrillation, Sudden Cardiac Death, Heart Failure, Intracranial Hemorrhage, Ischemic Stroke Arrhythmia and Electrophysiology Source Type: research

Related Links:

ConclusionsRA and AS in people without clinically apparent heart disease are associated with the occurrence of adverse changes in CMR.Key Points•RA and AS in people without clinically apparent heart disease are associated with the occurrence of adverse changes in CMR..•The independent risk factors for higher LVEF are AS occurrence, human B27 leukocyte antigen occurrence, higher NGAL concentration and higher BMI..•RA presence, methotrexate use, higher RF, higher NGAL, older age and higher BMI are independent risk factors for higher LV T2 ratio..•RA occurrence, AS occurrence, type 2 diabetes occurrence an...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
FOLATE, better known as vitamin B9, is undeniably crucial in the prevention of homocysteine toxicity; in addition, the B-complex vitamin is integral to healthy red blood cell production.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Levels are typically lower in the body through the winter months in northern latitudes.
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Nutrition Source Type: blogs
Around one-in-eight people are low in vitamin B12.
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Nutrition Source Type: blogs
Mol Biol Rep. 2021 Oct 15. doi: 10.1007/s11033-021-06781-4. Online ahead of print.ABSTRACTAging and age-related disorders have become one of the prominent issue of world. Oxidative stress due to overproduction of reactive oxygen species is the most significant cause of aging. The aim of literature compilation was to elucidate the therapeutic effect of vitamin C against oxidative stress. Various mediators with anti-inflammatory and anti-oxidant properties might be probable competitors of vitamin C for the improvement of innovative anti-aging treatments. More attention has been paid to vitamin C due to its anti-oxidant prope...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Source Type: research
Paediatr Respir Rev. 2021 Sep 23:S1526-0542(21)00092-0. doi: 10.1016/j.prrv.2021.09.004. Online ahead of print.ABSTRACTThis review addresses regional oxygenation and perfusion changes for preterm infants and changes with body position, with or without head rotation. Future directions for improving neurodevelopmental and clinical outcomes are suggested. The MEDLINE, Embase and Scopus databases were searched up to July 2021. Fifteen out of 470 studies met the inclusion criteria. All were prospective, observational studies with a moderate risk of bias. Significant variation was found for the baseline characteristics of the co...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Source Type: research
RATES of diabetes have doubled over the past 15 years, driven mainly by a sharp rise in obesity. A lack of treatments to reverse the condition means preventative measures, such as restrictive diets, are vital. When blood sugar levels are left unregulated, however, the blood vessels in the eye are some of the first in line to get damaged.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
LOW VITAMIN b12 is typically rectified by taking oral supplementation. However, if you are currently taking vitamin B12, you need to make sure you are not taking anything else that could lead to an unwanted reaction.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study in...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research Source Type: research
Incontinence products aren’t just for older adults, and there’s a variety of reasons a person may need incontinence products at some point in their life. Sometimes, it’s a short-term need, like after surgery or childbirth, or due to an infection or medication. But for some individuals, the need for incontinence products is long-term. Whether’s it’s caused by dementia or diabetes, stroke or special needs, MS or mental health disorders, incontinence represents a challenge for caregivers and the person with the diagnosis, as it impacts daily life in many ways.. Continue readin...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
More News: Arrhythmia | Atrial Fibrillation | Cardiology | Cardiovascular | Chronic Obstructive Pulmonary | Clinical Trials | Coumadin | Diabetes | Endocrinology | Heart | Heart Failure | Hemorrhagic Stroke | Ischemic Stroke | Peripheral Vascular Disease (PVD) | Pulmonary Thromboembolism | Stroke | Study | Vitamins | Warfarin