Drug Combo Shuts Down Stem Cells, Tumor Growth in Lung Cancer

JACKSONVILLE, Fla. — Researchers on Mayo Clinic’s Florida campus have shut down one of the most common and lethal forms of lung cancer by combining the rheumatoid arthritis drug auranofin with an experimental targeted agent. The combination therapy worked in a laboratory study to stop lung adenocarcinoma associated with mutation of the KRAS gene. The [...]
Source: Mayo Clinic Florida News - Category: Hospital Management Source Type: news

Related Links:

A growing link—what is the role of height in cancer risk?A growing link—what is the role of height in cancer risk?, Published online: 19 February 2019; doi:10.1038/s41416-018-0370-9A growing link—what is the role of height in cancer risk?
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults, Published online: 19 February 2019; doi:10.1038/s41416-018-0371-8Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Publication date: Available online 18 February 2019Source: Research in Veterinary ScienceAuthor(s): Hong-Xia Wang, Xi-Lan Lu, Wen-Jie Huang, Jian-Min ZhangAbstractThe aim of this study was to investigate the role of pyroptosis in the cryopreservation and transplantation of mouse ovarian tissues; the effects of pyroptosis inhibitior on the ovarian graft function were also explored. ICR (institute of cancer research) mice were randomly divided into control group and experimental groups (n = 10 per group). The experimental groups included fresh graft group (autograft), cryopreserved graft group (cryopreservation + aut...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
ConclusionsIntraarticular injections of 13 nm or 50 nm AuNPs showed an antioxidant action significantly raising catalase activity without causing negative effects on hematological indices. Prophylactic treatment with 50 nm more than with 13 nm AuNPs suppressed joint swelling, synovial angiogenesis and cartilage erosion in the initial stage of arthritis.
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
(MedPage Today) -- Also, how to prevent unplanned hospitalization for cancer patients
Source: MedPage Today Public Health - Category: American Health Source Type: news
Lupron (leuprolide acetate) is a type of hormone therapy for people with prostate cancer. Lupron is an injection drug, and doctors often prescribe it in combination with radiation therapy or surgery. As it lowers a person ’s testosterone levels, Lupron can cause a range of side effects. Learn more here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Prostate / Prostate Cancer Source Type: news
Publication date: Available online 18 February 2019Source: Journal of Molecular BiologyAuthor(s): María Soledad Cosentino, Camila Oses, Camila Vázquez Echegaray, Claudia Solari, Ariel Waisman, Yanina Álvarez, María Victoria Petrone, Marcos Francia, Marcelo Schultz, Gustavo Sevlever, Santiago Miriuka, Valeria Levi, Alejandra GubermanAbstractChromatin remodeling is fundamental for the dynamical changes in transcriptional programs that occur during development and stem cell differentiation. The histone acetyltransferase Kat6b is relevant for neurogenesis in mouse embryos and mutations of this gene ...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00318E, PaperJosu é Carvalho, Jéssica Lopes Nunes, Ana Catarina Lopes, Maria Paula Cabral Campello, António Rocha Paulo, João António Queiroz, Carla Cruz DNA aptamers represent a way to target cancer cells at a molecular level and continue to be developed with a view to improve treatment and imaging in cancer medicine. AT11-L0,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
In the present investigation, a collection of twenty two nerol derivatives, containing 1,2,3-triazolic appendages, was synthesized and screened in vitro for their cytotoxic activity against HL60, Nalm6, and Jurkat human leukemia cells as well as against B16F10 (melanoma cell line). In most cases, derivatives were able to reduce cell viability. The most potent compound (Z)-4-(((3,7-dimethylocta-2,6-dien-1-yl)oxy)methyl)-1-(4-(trifluoromethoxy)benzyl)-1H-1,2,3 triazole showed antiproliferative activity against Jurkat cells and reduced B16F10 cell migration. Physicochemical properties of the compounds were calculated in order...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
Electrochemical methods are powerful in the characterization and design of redox-modulating agents. We, herein, report the electrochemical investigation, in aprotic medium, of eleven synthetic 3-thio-substituted-nor-beta-lapachones, along with the determination of cytotoxic activity and correspondent selectivity index, against several cancer cell lines and one normal cell. Four of the quinones are novel compounds. The redox behavior is representative of two independent systems: the easy reduction of the quinone moiety and, at far more negative potential, the reductive cleavage of the C-S-C bonding; and the anodic part cont...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
More News: Adenocarcinoma | Arthritis | Cancer | Cancer & Oncology | Genetics | Hospital Management | Laboratory Medicine | Lung Cancer | Rheumatoid Arthritis | Rheumatology | Stem Cell Therapy | Stem Cells | Study