Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol

Conclusion
In conclusion, our study demonstrates a dose-dependent physiological effect of human IDOL on LDL metabolism in mice. This provides a potential model for preclinical testing of IDOL inhibitors for reduction of LDL-C levels.

Source: Cardiovascular Research - March 18, 2016 Category: Cardiology Authors: Ibrahim, S., Somanathan, S., Billheimer, J., Wilson, J. M., Rader, D. J. Tags: Integrative physiology and pathophysiology Source Type: research