Convection-enhancement delivery of liposomal formulation of oxaliplatin shows less toxicity than oxaliplatin yet maintains a similar median survival time in F98 glioma-bearing rat model

In conclusion, a better tumoral accumulation was achieved when oxaliplatin and Lipoxal™ were injected by CED. The liposomal encapsulation of oxaliplatin reduced its toxic, while maintaining its antitumor potential.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research

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Conditions:   Brain Tumor;   Glioma;   IDH Mutation Intervention:   Device: MR-scans using a 3T Prisma and a 7T Terra scanner (Siemens, Erlangen Germany) Sponsors:   University Hospital Inselspital, Berne;   Swiss National Science Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Contributors : Zhong Yao ; Xingang LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma multiforme (GBM) is the deadliest form of brain tumor with a median survival time of 15 months due to drug resistance. Ursodeoxycholic acid (UDCA) is approved of cancer suppressive potential in several tumors. Here we researched on the antitumor potential of UDCA on GBM. The CCK-8 and colony formation was used for detecting cell viability. RNA sequencing hinted transcriptional profile and pathways. PCR and western blot tested the change of related markers. Phenotype changes as cell cycle,...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
ConclusionsOur findings suggest that postoperative broadband power is of additional value in predicting PFS beyond already known predictors.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
Authors: Geng F, Lu GF, Ji MH, Kong DY, Wang SY, Tian H, Xie ZM, Pan M, Gong NL Abstract Glioma is a common malignant human brain tumor. The progression of glioma is associated with dysregulation of various microRNAs. Previous studies have demonstrated that microRNA-26b-3p (miR-26b-3p) is correlated with the pathogenesis of various tumors, but the functional role of miR-26b-3p and its underlying mechanisms in glioma are not clear. Here, we found that overexpression of miR-26b-3p repressed cell migration and proliferation and promoted apoptosis. In contrast, the opposite effects were observed when miR-26b-3p was inh...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Publication date: Available online 14 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Javier Figueroa, Alexis Morell, Veronica Bowory, Ashish H. Shah, Daniel Eichberg, Simon S. Buttrick, Angela Richardson, Christopher Sarkiss, Michael E. Ivan, Ricardo J. KomotarAbstractWith a recent trend towards supra-maximal resection for gliomas and minimally invasive techniques, keyhole temporal lobectomies may serve an important role in neurosurgical oncology. Due to their location and proximity to eloquent brain, temporal lobe gliomas offer unique challenges that may limit the extent of resection. Here we describe a mo...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
ConclusionHypoxia PET imaging has demonstrated potential benefits for grading, diagnostic and prognostic purposes, despite the lack of tangible results able to introduce such method in a wide clinical setting. MRI remains the gold standard in the morphologic evaluation of glioma, but the integration of results provided by18F-FMISO PET imaging concerning hypoxia might provide new crucial information in patients with glioma.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research
WEDNESDAY, Jan. 20, 2020 -- Surgical removal of the entire tumor may extend the lives of patients with a rare and deadly type of brain cancer called brainstem high-grade gliomas, a new study suggests. Researchers analyzed data from 103 patients in...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
CONCLUSION: VUGX01 can effectively block proliferation and induce apoptosis of certain type of cancer cells, even it's predicted by high LASSO score, but it is not an effective RTKs inhibitor, it may inhibit cell growth through acting as a novel ligand to one or several GPCRs. PMID: 31951182 [PubMed - as supplied by publisher]
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Authors: Tags: Curr Cancer Drug Targets Source Type: research
Conclusion Prior cortical activity as induced by the priming stimulation has a profound impact on the responsiveness to the nrTMS mapping paradigm. Our findings further showed that metaplasticity, a type of homeostatic plastic process, could be elicited even in cortical areas affected by a growing tumor. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - Category: Neurosurgery Authors: Tags: Original Article Source Type: research
CONCLUSIONS: GDC-0084 demonstrated classic PI3K/mTOR-inhibitor related toxicities. FDG-PET and concentration data from brain tumor tissue suggest that GDC-0084 crossed the blood-brain barrier. PMID: 31937616 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
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