Better way to treat abscesses: Add antibiotic to conventional approach

UCLA researchers have found that doctors can use a specific antibiotic in addition to surgically draining an abscess to give people a better chance of recovery. The discovery turns on its head the long-held notion that surgical drainage alone is sufficient for treating abscesses. The findings are particularly important because of the emergence of community-acquired methicillin-resistant Staphylococcus aureus, or MRSA, which since 2000 has become the most common cause of skin infections — initially in the U.S. and now in many other parts of the world. The UCLA study will be published March 3 by the New England Journal of Medicine. “We found that adding in a specific antibiotic to the medical treatment also resulted in fewer recurring infections, fewer infections in other places on the body and fewer people passing on the infection to other members of the household,” said Dr. David Talan, the study’s lead author and a professor in the department of emergency medicine and department of medicine, division of infectious diseases, at the David Geffen School of Medicine at UCLA and Olive View–UCLA Medical Center. “This translates into fewer medical visits and reduced health care costs.” Reed Hutchinson/UCLA Dr. Gregory Moran In the U.S., emergency department visits for skin infections nearly tripled from 1.2 million to 3.4 million between 1993 and 2005, and the burden of such infections has continued since then. Most of the increase was du...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Authors: Reissier S, Cattoir V Abstract INTRODUCTION: Streptogramins (pristinamycin and quinupristin-dalfopristin) can be interesting options for the treatment of infections due to Gram-positive cocci, especially multidrug-resistant isolates. AREAS COVERED: This review provides an updated overview on structural and activity characteristics, mechanisms of action and resistance, pharmacokinetic/pharmacodynamic and clinical use of streptogramins. EXPERT OPINION: The streptogramin antibiotics act by inhibition of the bacterial protein synthesis. They are composed of two chemically distinct compounds, namely typ...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Boosting the sensitivity of in vitroβ-lactam allergy diagnostic tests. Chem Commun (Camb). 2020 Oct 14;56(80):11973-11976 Authors: Peña-Mendizabal E, Morais S, Maquieira Á Abstract The synthesis of structurally new haptens and the development of suitable antigens are essential for boosting the sensitivity of drug allergy diagnostic testing. Unprecedented structural antigens for benzylpenicillin and amoxicillin are characterised and evaluated in a cohort of 70 subjects with a turnkey solution based on consumer electronics. PMID: 33033809 [PubMed - in process]
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research
Authors: Arab JP, Dirchwolf M, Álvares-da-Silva MR, Barrera F, Benítez C, Castellanos-Fernandez M, Castro-Narro G, Chavez-Tapia N, Chiodi D, Cotrim H, Cusi K, de Oliveira CPMS, Díaz J, Fassio E, Gerona S, Girala M, Hernandez N, Marciano S, Masson W, Mendez-Sanchez N, Leite N, Lozano A, Padilla M, Panduro A, Paraná R, Parise E, Perez M, Poniachik J, Restrepo JC, Ruf A, Silva M, Tagle M, Tapias M, Torres K, Vilar-Gomez E, Costa Gil JE, Gadano A, Arrese M Abstract Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide. NAFLD is the most frequently diagnosed chr...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Publication date: Available online 9 October 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Manuel Jorge Rial, Marcela Valverde, Victoria del Pozo, Francisco Javier González-Barcala, Carlos Martínez-Rivera, Xavier Muñoz, José María Olaguibel, Vicente Plaza, Elena Curto, Santiago Quirce, Pilar Barranco, Javier Domínguez-Ortega, Joaquin Mullol, César Picado, Antonio Valero, Irina Bobolea, Ebymar Arismendi, Paula Ribó, Joaquín Sastre
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
This study investigated antibacterial-producing Streptomyces isolated from the gut of estuarine fish Chanos chanos, emphasizing screening for the producer of peptide-containing antibacterial compounds. Eighteen isolates were found during preliminary screening, in which four isolates showed the best antibacterial activities. Based on the morphological, physiological, and biochemical characterization, as well as 16S rRNA partial sequencing, all of the four isolates belonged to Streptomyces. Three isolates were suspected as novel isolate candidates based on homology presentations and phylogenetic tree analysis. Disk-diffusion...
Source: International Journal of Microbiology - Category: Microbiology Tags: Int J Microbiol Source Type: research
Publication date: Available online 9 October 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Cezhi Du, Chengyong Wang, Jianbo Sui, Lijuan Zheng
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Trump plans in-person rally on Monday as next presidential debate cancelled; Europe records 100,000 daily cases for first time; Canada at ‘tipping point’. Follow latest updatesEurope: Spain declares emergency in Madrid as Berlin emerges as hotspotUK workers to get two-thirds of wages if firms told to shutAustralia: Is Victoria ready to come out of lockdown?US presidential debate cancelled – live updatesSee all our coronavirus coverage5.42amBSTMy colleagueLuke Henriques-Gomes has this story giving you a summary of the main Covid-19 stories from Australia.A main point of the day has beenVictoria ’s pr...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Science World news France Trump administration Donald Trump Source Type: news
CONCLUSION: There is a high prevalence of MRSA causing abscesses in the Hispanic population evaluated in an ED in Puerto Rico. Systemic antibiotic use for the treatment of skin abscesses after incision and drainage remains high despite published guidelines arguing against their widespread use. Clindamycin resistance in our patient population appears to be more frequent than previously reported. PMID: 33031694 [PubMed - as supplied by publisher]
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
Suppose two jumbo jets crashed every day, killing a total of about 365,000 people in a year. Remarkably enough that's about the level of carnage caused every year in our country by avoidable medical mistakes. We would never tolerate such an incredible loss of life were it caused by recurring plane crashes (or most anything else). The Federal Aviation Authority would be given immediate and unlimited funding to figure out exactly why the planes were crashing and to do whatever it takes to make them safe again. In fact, complete reporting of mistakes, and constantly correcting them, has made flying in a commercial plane abo...
Source: Science - The Huffington Post - Category: Science Source Type: news
Conclusion How many vaccinations will be considered to be a sensible number? If all of the vaccinations currently under development are deemed a success, how many of them will be added to the schedule? As there is little research to determine which ingredients are in the vaccinations listed as “under development” by the CDC, many parents are concerned about their toxicity and how best to protect their children. I will leave you with the wise words of Robert F, Kennedy Jr: “Vaccine industry money has neutralized virtually all of the checks and balances that once stood between a rapacious pharmaceutical ind...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Top Stories Christina England Logical Centers for Disease Control (CDC) World Health Organization (WHO) PhRMA Robert F. Kennedy Jr. Source Type: blogs
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