Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart

Conclusion
Apln-CreER-mediated lineage tracing distinguishes capillaries from large arteries, in both the neonatal and adult hearts. Through genetic fate mapping, we demonstrate that pre-existing arteries, but not capillaries, extensively contribute to collateral artery formation following myocardial injury. These results suggest that arteriogenesis is the major mechanism underlying collateral vessel formation.

Source: Cardiovascular Research - February 12, 2016 Category: Cardiology Authors: He, L., Liu, Q., Hu, T., Huang, X., Zhang, H., Tian, X., Yan, Y., Wang, L., Huang, Y., Miquerol, L., Wythe, J. D., Zhou, B. Tags: Vascular Biology Source Type: research