The Effect of Methylprednisolone on Plasma Concentrations of Neutrophil Gelatinase–Associated Lipocalin in Pediatric Heart Surgery*

Conclusions: Preoperatively administered methylprednisolone profoundly decreases plasma neutrophil gelatinase–associated lipocalin levels. Neutrophil gelatinase–associated lipocalin seems to originate to a significant extent from activated neutrophils. Preoperative methylprednisolone is a confounding factor when interpreting plasma neutrophil gelatinase–associated lipocalin levels as a kidney injury marker in pediatric heart surgery.
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research