On the Utility of ToxCastTM and ToxPi as Methods for Identifying New Obesogens
Conclusions: ToxCast PPARγ and RXRα assays do not correlate well with laboratory measurements of PPARγ and RXRα activity. The adipogenesis ToxPi performed poorly, perhaps due to the performance of ToxCast assays. We observed a modest predictive value of ToxCast for PPARγ and RXRα activation and adipogenesis and it is likely that many obesogenic chemicals remain to be identified.
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Citation: Janesick AS, Dimastrogiovanni G, Vanek L, Boulos C, Chamorro-García R, Tang W, Blumberg B. On the Utility of ToxCastTM and ToxPi as Methods for Identifying New Obesogens. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1510352
Received: 18 June 2015
Accepted: 7 December 2015
Advance Publication: 13 January 2016
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Source: EHP Research - Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research
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