On the Utility of ToxCastTM and ToxPi as Methods for Identifying New Obesogens

Conclusions: ToxCast PPARγ and RXRα assays do not correlate well with laboratory measurements of PPARγ and RXRα activity. The adipogenesis ToxPi performed poorly, perhaps due to the performance of ToxCast assays. We observed a modest predictive value of ToxCast for PPARγ and RXRα activation and adipogenesis and it is likely that many obesogenic chemicals remain to be identified. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Janesick AS, Dimastrogiovanni G, Vanek L, Boulos C, Chamorro-García R, Tang W, Blumberg B. On the Utility of ToxCastTM and ToxPi as Methods for Identifying New Obesogens. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1510352 Received: 18 June 2015 Accepted: 7 December 2015 Advance Publication: 13 January 2016 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the info...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research