Modulation of sympathetic activity and heart rate variability by ivabradine
Conclusions
(i) IVA-induced bradycardia was associated with increased SNA, resulting from baroreceptor unloading; if this applied to chronic IVA use in humans, it would be of relevance for therapeutic use of the drug. (ii) Whenever mean HR is concomitantly changed, time-domain HRV indexes should not be unequivocally interpreted in terms of autonomic balance.
Source: Cardiovascular Research - Category: Cardiology Authors: Dias da Silva, V. J., Tobaldini, E., Rocchetti, M., Wu, M. A., Malfatto, G., Montano, N., Zaza, A. Tags: Integrative physiology and pathophysiology Source Type: research
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