Modulation of sympathetic activity and heart rate variability by ivabradine

Conclusions (i) IVA-induced bradycardia was associated with increased SNA, resulting from baroreceptor unloading; if this applied to chronic IVA use in humans, it would be of relevance for therapeutic use of the drug. (ii) Whenever mean HR is concomitantly changed, time-domain HRV indexes should not be unequivocally interpreted in terms of autonomic balance.
Source: Cardiovascular Research - Category: Cardiology Authors: Tags: Integrative physiology and pathophysiology Source Type: research