What else could go wrong

Hello my fellow cfers. Im just going to jump right in, I'm 25 and I just finished my evaluation for transplant and found out I will be getting listed for both lung and liver. However, when I got a ct scan of my abdomen they saw some of the nodules on my liver do something called "washing out" which they said could be a sign of cancer. So about a week ago I had an MRI of my liver done and it is a small cancer. They said this wouldn't stop me from being listed but they want me to have a procedure to, the doctor I talked to, said "burn away the tumor". Im not really scared about the cancer part because I know it was only caused by my cirrhosis. The other thing is that during my evaluation I was told that I need to have a surgery to help stop my acid reflux, but the surgeon doesn't want to do it before my transplant because he doesn't think I would do well during or after. So I guess the reason I'm writing this is because I'm just getting so irritated and stressed. Its like one thing after another is coming up that just seems to complicate things further. Has anyone had to do any of these surgeries or procedures before, whether it was all at the same time or not? I feel like I just need to hear from someone that's done it, and that it is possible to get through so much. I usually don't doubt how strong I am or that I can't handle something, but this is getting to be a bit much even for me.
Source: Cystic Fibrosis Transplants Forum - Category: Respiratory Medicine Authors: Tags: Transplants Source Type: forums

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Conclusion: The integrated robotic system can place NBTU ablator at a desired target location in porcine brain and monitor the ablation in realtime via magnetic resonance thermal imaging (MRTI). Significance: Further optimization of this system could result in a clinically viable syste- for use in human trials for various diagnostic or therapeutic neurosurgical interventions.
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AbstractThe use of photobiomodulation therapy (PBMT) in the prevention of oral mucositis (OM) in paediatric care has increased. In this article, we report data of paediatric oncology/haematopoietic stem cell transplantation (HSCT) patients treated with PBMT to prevent chemotherapy-induced OM. A retrospective study was conducted at a Brazilian referral service. Prophylactic PBMT was used in children and adolescents ( ≤ 17 years) following the protocol: InGaAIP, 660 nm, 100 mW, 2 J, 3.33 W/cm2, and 20 s per point. Demographic data and OM severity scores were assessed. A regression model tested the association between OM w...
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CONCLUSIONS: The transplanted donor's lungs were not influenced by indium in the recipient's organs. Bilateral LT is thus an effective treatment option in severe indium lung disease cases. PMID: 32951288 [PubMed - in process]
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Tumor immunosuppression is a limiting factor for successful cancer therapy. The lipid sphingosine-1-phosphate (S1P), which signals through 5 distinct G protein–coupled receptors (S1PR1–5), has emerged as an important regulator of carcinogenesis. However, the utility of targeting S1P in tumors is hindered by S1P’s impact on immune cell trafficking. Here, we report that ablation of the immune cell–specific receptor S1PR4, which plays a minor role in immune cell trafficking, delayed tumor development and improved therapy success in murine models of mammary and colitis-associated colorectal cancer throu...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ03863F, PaperSk. Abdul Amin, Kalyan Ghosh, Dipayan Mondal, Tarun Jha, Shovanlal Gayen In human, the over-expression of Mcl-1 protein causes the different cancers and it is also responsible for cancer resistance to different cytotoxic agents. Thus, discovery of potential inhibitors of Mcl-1... The content of this RSS Feed (c) The Royal Society of Chemistry
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Contributor : Shengtao ZhouSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensOvarian cancer is a heterogeneous disease that constitutes great menace to female health and poses tremendous clinical challenge. Based on unsupervised classification of whole-genome gene expression profiles, four molecular subtypes of ovarian cancer were recently identified. However, currently it is still unelucidated on the immune infiltration pattern of different molecular subtypes of ovarian cancer. we used a computational approach (CIBERSORT) to bulk...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : M Schmidt ; M GehrmannSeries Type : Expression profiling by arrayOrganism : Homo sapiensInterferons are crucial for adaptive immunity and play an important role in the immune landscape of breast cancer. Using microarray-based gene expression analysis, we examined the subtype specific prognostic significance of interferon- γ (IFN-γ) as a single gene as well as an IFN-γ signature covering the signaling pathway in 461 breast cancer patients. Prognostic significance of IFN-γ as well as the IFN-γ signature for metastasis-free survival (MFS) were examined using Kaplan Meier as well as...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Jose C Reyes ; Jose A Guerrero-Mart ínezSeries Type : OtherOrganism : Mus musculusTGF β cytokines have crucial roles in development, proliferation, tissue homeostasis, differentiation, and immune regulation. Consequently, alterations in TGFβ signaling underlie numerous diseases, including cancer. Moreover TGFβ is one of the most potent inductors of EMT (epithelial to mesenchymal transition) in normal and oncogenic epithelial cells from different origins. During EMT, cells undergo an extensive reorganization of cell adhesion complexes, cytoskeletal architecture, and extracellular matrix ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
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