Utilizing network pharmacology, molecular docking, and animal models to explore the therapeutic potential of the WenYang FuYuan recipe for cerebral ischemia-reperfusion injury through AGE-RAGE and NF- κB/p38MAPK signaling pathway modulation

CONCLUSION: This study utilized network pharmacology, molecular docking, and animal experiments to identify the potential mechanism of the WenYang FuYuan recipe, which may be associated with the regulation of the AGE-RAGE signaling pathway and the inhibition of target proteins and mRNAs in the downstream NF-kB/p38MAPK pathway.PMID:38697555 | DOI:10.1016/j.exger.2024.112448

Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Ding Zhang Hongling Qin Wei Chen Junjun Xiang Minghe Jiang Ling Zhang Keqing Zhou Yueqiang Hu Source Type: research