Efficacy and safety of N-acetyl-L-leucine in patients with ataxia telangiectasia: A randomized, double-blind, placebo-controlled, crossover clinical trial

CONCLUSIONS: To the best of our knowledge, this was the first placebo-controlled, randomized clinical trial exploring NALL's potential effects for treating AT. Despite improvements in some symptomss, NALL intervention failed to improve motor function significantly. However, patients' nausea and constipation were improved by NALL, which can be a relevant benefit clinically.PMID:38669738 | DOI:10.1016/j.ejpn.2024.04.009

Source: European Journal of Paediatric Neurology - April 26, 2024 Category: Neurology Authors: Mehran Beyraghi-Tousi Amirhosein Sahebkar Mahsa Houra Pooria Sarvghadi Tannaz Jamialahmadi Reza Bagheri Shima Tavallaie Eric Gumpricht Maryam Saberi-Karimian Source Type: research