Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling

CONCLUSIONS: Our study reveals that interactions between CX3CR1 and CX3CL1 can modify CCM neuropathology when lesions are accelerated by environmental hypoxia. Moreover, a hypoxic environment or hypoxia signaling caused by CCM disease influences the balance between neuroinflammation and neuroprotection mediated by CX3CR1-CX3CL1 signaling. These results establish CX3CR1 as a genetic marker for patient stratification and a potential predictor of CCM aggressiveness.PMID:38660801 | DOI:10.1161/ATVBAHA.123.320367

Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Eduardo Frias-Anaya Helios Gallego-Gutierrez Brendan Gongol Shantel Weinsheimer Catherine Chinhchu Lai Marco Orecchioni Aditya Sriram Cassandra M Bui Bliss Nelsen Preston Hale Angela Pham Robert Shenkar Dorothy DeBiasse Rhonda Lightle Romuald Girard Ying Source Type: research