Melatonin Mitigates the Progression of Chemically Induced Hepatocellular Carcinoma in Rats via Targeting Wnt/ Β-Catenin Pathway, and Small Noncoding miR-let-7b

CONCLUSIONS: Melatonin exerted hepatic immunomodulating changes, in addition to proapoptotic and antiangiogenic effects, illustrated by increased IL-2, caspase-3, and decreased VEGF levels, respectively. Moreover, the use of melatonin during hepatocarcinogenesis positively modulated the disrupted expression of microRNA let7b and Wnt/β-catenin significantly.PMID:38618269 | PMC:PMC11015929 | DOI:10.61186/rbmb.12.3.403
Source: Mol Biol Cell - Category: Molecular Biology Authors: Source Type: research