Linc-NSC affects cell differentiation, apoptosis and proliferation in  mouse neural stem cells and embryonic stem cells in vitro and in vivo

CONCLUSIONS: Our analyses demonstrated that linc-NSC, a promising gene-edited target, may promote the differentiation of mouse NSCs and inhibit tumorigenesis in mouse ESCs. The knockdown of linc-NSC inhibited the apoptosis in NSCs both in vitro and in vivo, and prevented tumor formation, revealing a new dimension into the effect of lncRNA on low survival NSCs and providing a prospective gene manipulation target prior to transplantation. In parallel, the overexpression of linc-NSC induced apoptosis in ESCs both in vitro and in vivo and attenuated the tumorigenicity of ESCs in vivo, but did not completely prevent tumor formation.PMID:38615283 | DOI:10.1007/s00018-024-05224-0
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Source Type: research