Linc-NSC affects cell differentiation, apoptosis and proliferation in mouse neural stem cells and embryonic stem cells in vitro and in vivo
CONCLUSIONS: Our analyses demonstrated that linc-NSC, a promising gene-edited target, may promote the differentiation of mouse NSCs and inhibit tumorigenesis in mouse ESCs. The knockdown of linc-NSC inhibited the apoptosis in NSCs both in vitro and in vivo, and prevented tumor formation, revealing a new dimension into the effect of lncRNA on low survival NSCs and providing a prospective gene manipulation target prior to transplantation. In parallel, the overexpression of linc-NSC induced apoptosis in ESCs both in vitro and in vivo and attenuated the tumorigenicity of ESCs in vivo, but did not completely prevent tumor formation.PMID:38615283 | DOI:10.1007/s00018-024-05224-0
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Lili Guo Dan Zou Wenqiao Qiu Fan Fei Lihua Chen Wenjin Chen Huan Xiong Xinda Li Yangyang Wang Mingjun Gao Jianwei Zhu Jin Zhang Yunsen He Mou Gao Ruxiang Xu Source Type: research
More News: Brain | Cytology | Genetics | Neurology | Stem Cell Therapy | Stem Cells | Study | Transplants