The Impact of Genetic Polymorphism on Complications Development in Heart Failure Patients

Purpose: Congestive heart failure (HF) is a heterogeneous life-threatening syndrome. Heart transplantation (HT) is one of the gold standard treatment at the end-stage of HF. On the other hand, implantation of the mechanical circulatory support (MCS) device is an alternative treatment which improves patient ’s quality of life. However, HF patients have development of the thrombosis and bleeding complications due to the non-physiologic shear-stress and incorrect dosage of antiplatelet drugs. The aim of our research was to identify influence of UGT1A6 gene polymorphism and its impact on the development of the complications in HF patients after MCS implantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research