Statins Reduce Inflammation, Oxidative Stress and Endothelial Cell Activation in a Model of Venous Congestion in Systolic Heart Failure Patients

Purpose: Acute decompensated heart failure (ADHF) is characterized by venous congestion (VC) and elevation in biomarkers of inflammation, oxidative stress and endothelial cell (EC) activation. Secondary analyses of HF studies suggest that statins may reduce ADHF events; however, the mechanisms remain unclear. Here, we tested whether background treatment with statins buffers inflammation, oxidative stress and EC activation in an experimental model of VC among systolic HF pts.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: F. Castagna, B.Z. Wang, B. Fine, S. Jelic, D. Onat, A. Ladanyi, K. Wong, R.A. Friedman, F. Cal ì, A. Pinsino, R. Demmer, M. Yuzefpolskaya, Source Type: research