Transcriptional Changes in Dilated Cardiomyopathy After LVAD Treatment

Purpose: Dilated cardiomyopathy (DCM) is characterized by transcriptional changes. Clinical recovery after LVAD implant is highly variable and transcriptional changes often persist. Our goal was to identify micro-RNAs (miRNAs) associated with heart failure (HF) and to evaluate responses to LVAD therapy to better understand epigenetic mechanisms regulating differential gene expression (DGE).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research