Stabilizing tumor resident mast cells restores T cell infiltration and sensitizes sarcomas to PD-L1 inhibition

CONCLUSIONS: Our study suggests the targeting of MCs with clinically administered drugs, such as antihistamines, as a promising approach to overcome resistance to immunotherapy in sarcomas.PMID:38578281 | DOI:10.1158/1078-0432.CCR-24-0246

Source: Clinical Cancer Research - April 5, 2024 Category: Cancer & Oncology Authors: Myrofora Panagi Fotios Mpekris Chrysovalantis Voutouri Andreas G Hadjigeorgiou Chloe Symeonidou Eleni Porfyriou Christina Michael Andreas Stylianou John D Martin Horacio Cabral Anastasia Constantinidou Triantafyllos Stylianopoulos Source Type: research