A Novel Human Interleukin ‐23A Overexpressing Mouse Model of Systemic Lupus Erythematosus

ConclusionWe have generated and characterized a novel genetic mouse model of SLE, providing proof-of-concept for the etiopathogenic role of human IL-23A. This new model has a normal life span and integrates several characteristics of the human disease's complexity and chronicity, making it an attractive preclinical tool for studying IL-23 –dependent pathogenic mechanisms and assessing the efficacy of anti–human IL-23A or modeled disease-related therapeutics.

Source: Arthritis and Rheumatology - April 3, 2024 Category: Rheumatology Authors: Eleni Christodoulou ‐Vafeiadou, Christina Geka, Lida Iliopoulou, Lydia Ntari, Maria C. Denis, Niki Karagianni, George Kollias Tags: Full Length Source Type: research