Transcriptomic profiling of sciatic nerves and dorsal root ganglia reveals site-specific effects of prediabetic neuropathy

Peripheral neuropathy (PN) is a severe and frequent complication of obesity, prediabetes, and type 2 diabetes characterized by progressive distal-to-proximal peripheral nerve degeneration. However, a comprehensive understanding of the mechanisms underlying PN, and whether these mechanisms change during PN progression, is currently lacking. Here, gene expression data were obtained from distal (sciatic nerve; SCN) and proximal (dorsal root ganglia; DRG) injury sites of a high-fat diet (HFD)-induced mouse model of obesity/prediabetes at early and late disease stages.

Source: Translational Research - March 29, 2024 Category: Research Authors: St éphanie A. Eid, Sarah E. Elzinga, Kai Guo, Lucy M. Hinder, John M. Hayes, Crystal M. Pacut, Emily J. Koubek, Junguk Hur, Eva L. Feldman Source Type: research