Metformin Use in Type 2 Diabetics and Delirium After Noncardiac Surgery: A Retrospective Cohort Analysis

CONCLUSIONS: Chronic metformin use was associated with slightly and nonsignificantly less delirium. However, patients who used metformin had clinically meaningfully fewer major complications, mostly stage 2 to 3 kidney injury. While not statistically significant, the reduction was substantial and warrants further investigation because there is currently no effective preventive measure for perioperative renal injury. Benefit would be especially meaningful if it could be produced by acute perioperative treatment. Finally, metformin was associated with faster hospital discharge, although not by a clinically meaningful amount.PMID:38517762 | DOI:10.1213/ANE.0000000000006863

Source: Anesthesia and Analgesia - March 22, 2024 Category: Anesthesiology Authors: Stephania Paredes Ayoub Harb Julian R össler Maede Zookaei Nikoo Kurt Ruetzler Alparslan Turan Xuan Pu Daniel I Sessler Source Type: research