IFN ‑γ induces apoptosis in gemcitabine‑resistant pancreatic cancer cells

In conclusion, IFN‑γ exhibited antitumor immune properties by upregulating MRP and downregulating BCRP expression, reversing drug‑resistance gene expression, and reducing cell viability and migration, while promoting apoptosis in PANC‑1/GEM cells. IFN‑γ could potentially serve as a treatment option for patients with GEM‑resistant pancreatic cancer.PMID:38488034 | DOI:10.3892/mmr.2024.13200
Source: Molecular Medicine Reports - Category: Molecular Biology Authors: Source Type: research