Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease

CONCLUSIONS: In cultured MDMs from SSc-ILD pts, nintedanib seems to downregulate the profibrotic M2 phenotype through the significant reduction of gene expression and protein synthesis of M2 cell surface markers, together with the significant reduction of TGFβ1 release, and notably MerTK, a tyrosine kinase receptor involved in lung fibrosis.PMID:38509595 | DOI:10.1186/s13075-024-03308-7

Source: Cell Research - March 21, 2024 Category: Cytology Authors: Stefano Soldano Vanessa Smith Paola Montagna Emanuele Gotelli Rosanna Campitiello Carmen Pizzorni Sabrina Paolino Alberto Sulli Andrea Cere Maurizio Cutolo Source Type: research