The estrogen receptor alpha regulates the sex-dependent expression and pronociceptive role of bestrophin-1 in neuropathic rats

This study investigated if 17 β-estradiol and estrogen receptor alpha (ERα) activation regulate bestrophin-1 activity and expression in neuropathic rats. Neuropathic pain was induced by L5-spinal nerve transection (SNT). Intrathecal administration of CaCCinh-A01 (0.1-1 µg), a CaCC blocker, reversed tactile allodynia induced b y SNT in female but not male rats.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Original Reports Source Type: research