Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers

Conclusion
Nebulette is dispensable for normal cardiac function, although Z-line widening and up-regulation of cardiac stress markers were found in nebl–/– heart. These results suggest that the nebulette disease causing mutations have dominant gain-of-function effects.

Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Mastrototaro, G., Liang, X., Li, X., Carullo, P., Piroddi, N., Tesi, C., Gu, Y., Dalton, N. D., Peterson, K. L., Poggesi, C., Sheikh, F., Chen, J., Bang, M.-L. Tags: Cardiac biology and remodelling Source Type: research