Prophylactic corticosteroids for cardiopulmonary bypass in adult cardiac surgery

CONCLUSIONS: A systematic review of trials evaluating the organ protective effects of corticosteroids in cardiac surgery demonstrated little or no treatment effect on mortality, gastrointestinal bleeding, and renal failure. There were opposing treatment effects on cardiac and pulmonary complications, with evidence that corticosteroids may increase cardiac complications but reduce pulmonary complications; however, the level of certainty for these estimates was low. There were minor benefits from corticosteroid therapy for infectious complications, but the evidence on hospital length of stay was very uncertain. The inconsistent treatment effects across different outcomes and the limited data on high-risk groups reduced the applicability of the findings. Further research should explore the role of these drugs in specific, vulnerable cohorts.PMID:38506343 | DOI:10.1002/14651858.CD005566.pub4

Source: Cochrane Database of Systematic Reviews - March 20, 2024 Category: General Medicine Authors: Riccardo Giuseppe Abbasciano Guido Maria Olivieri Rachel Chubsey Francesca Gatta Nathan Tyson Keertana Easwarakumar Daniel P Fudulu Roberto Marsico Markus Kofler Ghazi Elshafie Florence Lai Mahmoud Loubani Simon Kendall Mustafa Zakkar Gavin J Murphy Source Type: research