Metformin and progestins in women with atypical hyperplasia or endometrial cancer: systematic review and meta-analysis

CONCLUSION: Combined therapy is effective. Metformin shows superiority to the standard regimen in achieving better CR rate in patients with AEH and benefits pregnancy rates but not recurrence or live birth rates. Therefore, the ideal fertility-sparing treatment for EC has not yet been determined and further clinical trials are needed.PMID:38503850 | DOI:10.1007/s00404-024-07416-2

Source: Cancer Control - March 20, 2024 Category: Cancer & Oncology Authors: Leila Adamyan Laura Pivazyan Sapiyat Isaeva Roman Shapovalenko Araksya Zakaryan Source Type: research