Upregulation of the histone γ-H2AX correlates with worse patient survival and basal-like subtype in pancreatic ductal adenocarcinoma

Conclusionγ-H2AX can be characterized as a predictive biomarker for poorer patient survival. Consequently, upcoming clinical trials focused on the efficacy of targeted therapies influencing the DNA repair system and radiotherapy should evaluate γ-H2AX as a potential biomarker for therapy response. Furthermo re, γ-H2AX may serve as a viable target for treatment in the future.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research