Regional delivery of mesothelin-targeted chimeric antigen receptor T-cell effectively and safely targets colorectal cancer liver metastases in mice

CONCLUSIONS: Regional delivery of MSLN-targeted CAR T-cell therapy has encouraging results in the orthotopic CRLM NSG mouse model and PDX model, and converts the tumor microenvironment from cold to hot. This study may provide a new therapeutic approach for CRLM. Further clinical study is needed.PMID:38482238 | PMC:PMC10932675 | DOI:10.21037/jgo-24-25

Source: Cancer Control - March 14, 2024 Category: Cancer & Oncology Authors: Xin Zhou Minjie Yang Jiaze Yu Jingwen Tan Nan Xu Yongjie Zhou Wen Zhang Jingqin Ma Zihan Zhang Alex Friedlaender Justin Taylor Lei Yu Zhiping Yan Source Type: research