Implications of Rapid Molecular Responses to Induction Chemotherapy (IC) in Human Papilloma Virus (HPV) Head and Neck Squamous Cell Carcinoma (HNSCC).

Patients with locally advanced (LA) HPV HNSCC are treated with various types of IC and/or standard (sd) or reduced dose (rd) of chemoradiation (CRT). Chemotherapy only (TPF) or with immunotherapy (TP-PD1) are the main IC types used prior to CRT or surgery. Tumor tissue modified viral HPV DNA (TTMV) is a sensitive and specific biomarker for HPV+ HNSCC. Therefore, TTMV may be useful to match patients with the appropriate intensity of treatment while minimizing toxicity. However, how TTMV levels may be used to guide the treatment of HNSCC is not yet established.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: 127 Source Type: research