Neurologic changes induced by whole-brain synchrotron microbeam irradiation: 10 months behavioral and veterinary follow-up

CONCLUSIONS: While acute toxicity of microbeam exposures depends on very high peak doses, late toxicity mainly relates to delivery of high MBI valley doses. MBI seems to elicit low impact on normal rat behavior but further tests are warranted to fully explore this hypothesis. However, high peak and valley doses are well tolerated from a veterinary point of view. This normal tissue tolerance to whole-brain, high-dose MBI reveals a promising avenue for MRT, i.e., therapeutic applications of microbeams which are poised for translation to a clinical environment.PMID:38462014 | DOI:10.1016/j.ijrobp.2024.02.053

Source: Health Physics - March 10, 2024 Category: Physics Authors: L Eling C Verry J Balosso I Flandin S Kefs A Bouchet J F Adam J A Laissue R Serduc Source Type: research