Extracellular cancer ‑associated fibroblasts: A novel subgroup in the cervical cancer microenvironment that exhibits tumor‑promoting roles and prognosis biomarker functions
In conclusion, the present study assessed the heterogeneity of CAFs in the cervical cancer microenvironment, and a subgroup of CAFs that may be closely associated with tumor progression was defined. Moreover, a signature based on the hub genes of ecCAFs was shown to have biomarker functionality in terms of predicting survival rates, and therefore this CAF subgroup may become a therapeutic target for cervical cancer in the future.PMID:38449793 | PMC:PMC10915806 | DOI:10.3892/ol.2024.14300
Source: Oncology Letters - Category: Cancer & Oncology Authors: Yuehan Wang Mingxia Xu Yeli Yao Ying Li Songfa Zhang Yunfeng Fu Xinyu Wang Source Type: research