Untargeted metabolomic profiling reveals molecular signatures associated with type 2 diabetes in Nigerians
CONCLUSIONS: We demonstrate that metabolomic dysregulation associated with T2D in Nigerians affects multiple processes, including glycolysis, free fatty acid and bile metabolism, and branched chain amino acid catabolism. Our study replicated previous findings in other populations and identified a metabolic signature that could be used as a biomarker panel of T2D risk and glycemic control thus enhancing our knowledge of molecular pathophysiologic changes in T2D. The metabolomics dataset generated in this study represents an invaluable addition to publicly available multi-omics data on understudied African ancestry populations.PMID:38444015 | DOI:10.1186/s13073-024-01308-5
Source: Cancer Control - Category: Cancer & Oncology Authors: Ayo P Doumatey Daniel Shriner Jie Zhou Lin Lei Guanjie Chen Omolara Oluwasola-Taiwo Susan Nkem Adela Ogundeji Sally N Adebamowo Amy R Bentley Mateus H Gouveia Karlijn A C Meeks Clement A Adebamowo Adebowale A Adeyemo Charles N Rotimi Source Type: research
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