Investigating the impact of hypertension with and without diabetes on Alzheimer's disease risk: A clinico-pathological study
DISCUSSION: HTN+/DM+ and HTN+/DM- increased AD risk compared to HTN-/DM-, but pathological differences between groups suggest targeted therapies may be warranted based on cardiovascular risk profiles.HIGHLIGHTS: AD risk was studied in hypertensive (HTN+) individuals with/without diabetes (DM+/-). HTN+/DM+ and HTN+/DM- both had an increased risk of AD compared to HTN-/DM-. Post mortem analysis identified neuropathological differences between HTN+/DM+ and HTN+/DM-. In HTN+/DM+, AD risk was greater in those with AD neuropathology and CAA. In HTN+/DM-, AD risk was greater in those with cerebrovascular neuropathology.PMID:38425134 | DOI:10.1002/alz.13717
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Myuri Ruthirakuhan Walter Swardfager Lisa Xiong Bradley J MacIntosh Jennifer S Rabin Krista L Lanct ôt Julie Ottoy Joel Ramirez Julia Keith Sandra E Black Source Type: research
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