Recent Developments in Nanotechnology and Immunotherapy for the Diagnosis and Treatment of Pancreatic Cancer

Curr Pharm Biotechnol. 2024 Feb 23. doi: 10.2174/0113892010284407240212110745. Online ahead of print.ABSTRACTPancreatic cancer kills millions of people worldwide each year and is one of the most prevalent causes of mortality that requires prompt therapy. A large number of people who have pancreatic cancer are detected at an advanced stage, with incurable and drug-resistant tumors. Hence the overall survival rate of pancreatic cancer is less. The advance phase of this cancer is generated because of the expression of the cancer-causing gene, inactivation of the tumorsuppressing gene, and deregulation of molecules in different cellular signalling pathways. The prompt diagnosis through the biomarkers significantly evades the progress and accelerates the survival rates. The overexpression of Mesothelin, Urokinase plasminogen activator, IGFR, Epidermal growth factor receptor, Plectin-1, Mucin-1 and Zinc transporter 4 were recognized in the diagnosis of pancreatic cancer. Nanotechnology has led to the development of nanocarriersbased formulations (lipid, polymer, inorganic, carbon-based and advanced nanocarriers) that overcome the hurdles of conventional therapy, chemotherapy and radiotherapy, which causes toxicity to adjacent healthy tissues. Biocompatibility, toxicity and large-scale manufacturing are the hurdles associated with the nanocarriers-based approaches. Currently, Immunotherapy-based techniques have emerged as an efficient therapeutic alternative for the prevention of ca...
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Source Type: research