Neurodegenerative effects of air pollutant Particles: Biological mechanisms implicated for Early-Onset Alzheimer's disease

CONCLUSIONS: This study provides insights into the mechanistic links between inflammation and oxidative stress to pollutant particle-induced AD pathologies, with magnetite apparently inducing the most pathological effects. No exacerbation of the effects was observed in the AD-predisposed model when compared to the wild-type, indicating a particle-induced neurodegeneration that is independent of disease state.PMID:38412566 | DOI:10.1016/j.envint.2024.108512

Source: Environment International - February 27, 2024 Category: Environmental Health Authors: Cindy Gunawan Charlotte Fleming Peter J Irga Roong Jien Wong Rose Amal Fraser R Torpy S Mojtaba Golzan Kristine C McGrath Source Type: research