Musculoskeletal health worsened from carnitine supplementation and not impacted by a novel individualized treadmill training protocol

CONCLUSION: Carnitine supplementation worsened CKD progression, mineral metabolism biochemistries and cortical porosity, and did not have an impact on physical function. Individualized treadmill running improved maximal aerobic capacity but did not have an impact on CKD progression or bone properties. Future studies should seek to better understand carnitine doses in conditions of compromised renal function to prevent toxicity which may result from elevated carnitine levels and to optimize exercise prescriptions for musculoskeletal health.PMID:38377965 | DOI:10.1159/000537827

Source: American Journal of Nephrology - February 20, 2024 Category: Urology & Nephrology Authors: Ashley D Troutman Shruthi Srinivasan Corinne E Metzger Paul B Fallen Neal Chen Kalisha D O'Neill Matthew R Allen Annabel Biruete Sharon M Moe Keith G Avin Source Type: research