Valvular Prostaglandins Are Elevated in Severe Human Aortic Valve Stenosis

CONCLUSIONS: Our comprehensive analysis of oxylipins in the human AV identified the inflammatory and osteogenic regulating prostanoids to be positively correlated with AVS severity. This elucidation of prostanoid dysregulation warrants further research into COX inhibition to mitigate AVS.PMID:38357817 | DOI:10.1161/ATVBAHA.123.320001

Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Lucien G J Cayer Arun Surendran Tobias Karakach Harold M Aukema Amir Ravandi Source Type: research