A Novel human IL ‐23A Overexpressing Mouse Model of Systemic Lupus Erythematosus
ConclusionsWe have generated and characterized a novel genetic mouse model of SLE, providing proof-of-concept for the etiopathogenic role of hIL-23A. This new model has a normal lifespan and integrates several characteristics of the human disease's complexity and chronicity making it an attractive preclinical tool for studying IL23-dependent pathogenic mechanisms and assessing the efficacy of anti-hIL23A or modeled disease-related therapeutics.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Eleni Christodoulou ‐Vafeiadou,
Christina Geka,
Lida Iliopoulou,
Lydia Ntari,
Maria C. Denis,
Niki Karagianni,
George Kollias Tags: Full Length Source Type: research
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