Cancers, Vol. 16, Pages 849: Lynch Syndrome: From Multidisciplinary Management to Precision Prevention

Conclusions: Although robust diagnostic algorithms, including prompt testing of tumor tissue for MMR defects and referral for genetic counselling, currently exist for suspected LS in CRC patients, the indications for LS screening in cancer-free individuals still need to be refined and standardized. Investigation into additional genetic and non-genetic factors that may explain residual rates of interval cancers, even in properly screened populations, would allow for more tailored preventive strategies.

Source: Cancers - February 20, 2024 Category: Cancer & Oncology Authors: Arianna Dal Buono Alberto Puccini Gianluca Franchellucci Marco Airoldi Michela Bartolini Paolo Bianchi Armando Santoro Alessandro Repici Cesare Hassan Tags: Review Source Type: research