PVT1 promotes proliferation and macrophage immunosuppressive polarization through STAT1 and CX3CL1 regulation in glioblastoma multiforme

CONCLUSION: PVT1 plays a significant role in GBM, correlating with poor prognosis, promoting cell growth, and shaping an immunosuppressive TME via STAT1 and CX3CL1 regulation. Targeting PVT1 may hold therapeutic promise for GBM patients.PMID:38287522 | PMC:PMC10805395 | DOI:10.1111/cns.14566

Source: CNS Neuroscience and Therapeutics - January 30, 2024 Category: Neuroscience Authors: Lijie Huang Zheng Wang Chihyi Liao Zheng Zhao Hua Gao Ruoyu Huang Jing Chen Fan Wu Fan Zeng Ying Zhang Tao Jiang Huimin Hu Source Type: research