IP < sub > 3 < /sub > R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin

CONCLUSION: Melatonin prevents the formation of MAMs via the MR-ERK1/2-FoxO1-IP3R1 pathway, thereby alleviating the development of MT-induced liver injury. Melatonin-modulated MAMs may be a promising therapeutic therapy for traumatic hepatic injury.PMID:38308199 | PMC:PMC10836028 | DOI:10.1186/s11658-023-00509-x

Source: Cellular and Molecular Biology Letters - February 2, 2024 Category: Biochemistry Authors: Rui Shi Zhenhua Liu Huan Yue Man Li Simin Liu Dema De Runjing Li Yunan Chen Shuli Cheng Xiaoming Gu Min Jia Jun Li Juan Li Shumiao Zhang Na Feng Rong Fan Feng Fu Yali Liu Mingge Ding Jianming Pei Source Type: research